Thursday, July 09, 2009

Role of leptin in the pathophysiology of nasal polyposis

Leptin which is an antiobesity protein is also suspected to play a role in the pathophysiology of nasal polyposis. The term leptin is derived from the Greek work leptos which means thin. Molecularly speaking it is a 16 kilodalton protein molecule which is playing a key role in regulating energy expenditure which includes appetite and metabolism. This protein molecule is coded by the Ob(Lep) gene located in chromosome 7 in humans.
Leptin was first discovered by Friedmann in 1994.He identified that white adipose tissue is the main source of synthesis of Leptin. He also postulated that leptin could be an important biomarker for body fat. Patients who are fasting or on very low calorie diet have low levels of serum leptin.

Studies have shown that serum levels of Leptin is found to be elevated in patients with nasal polyposis.

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